The standard solution contains 4% paraformaldehyde in 0. In addition, paraformaldehyde is used as a fungicide and bactericide in industries as varied as crude oil production, beet sugar refining, and warehousing. Formaldehyde 32% in aqueous solution, em grade vwr. Aiha erpgamerican industrial hygiene associations emergency response planning guidelines. Firstaid measures general advice if symptoms persist, call a physician. Formaldehyde, 37% ww safety data sheet according to federal register vol. The data in thls material safety data sheet nelates only to the. You can buy em grade formaldehyde or you can make your own. Formaldehyde solution 37 ww, stablized with 1012% methanol.
Composition and information on ingredients composition. If inhaled if breathed in, move person into fresh air. Formaldehyde the ubiquitous substance chho is a naturally occurring substance but is often used in a manmade way. Many laboratories at uw use formalin solutions and paraformaldehyde solutions or solids as part of their research and clinical activities. Paraformaldehyde may react violently with strong oxidizing agents hydrogen peroxide, performic acid, perchloric acid in the presence of aniline, potassium permanganate, nitromethane. Paraformaldehyde pfa is the smallest polyoxymethylene, the polymerization product of formaldehyde with a typical degree of polymerization of 8100 units. The company operates in more than 30 countries and delivers an extensive portfolio of products and services. Paraformaldehyde is the most commonly used fixative employed for fixation of tissues and cells in immunohistochemistry and immunocytochemistry protocols. Prevent entry into sewers, water courses, basements or confined areas. Give artificial respiration only if breathing has stopped.
Paraformaldehyde is somewhat moisturesensitive and over time tends to sublime, forming formaldehyde gas. Formalin and paraformaldehyde solutions can emit formaldehyde gas, a known human carcinogen, and can irritate the eyes and skin. Msds, 1574 1574100, 4% paraformaldehyde formaldehyde aqueous solution. Paraformaldehyde is on the right to know hazardous. Skin contact wash off immediately with plenty of water for at least 15 minutes.
H334 may cause allergy or asthma symptoms or breathing difficulties if inhaled. Limited evidence of carcinogenicity in animal studies iarc. Paraformaldehyde 4% aqueous solution, em grade contd. Accidental release measures environmental precautions stop leak if without risk. Sheet msds and the label to determine product ingredients and. Exposure was stopped during the first week for the middle and high dose groups due to high mortality. Central file or hazard communication standard file. Show this safety data sheet to the doctor in attendance.
Inflammation of upper respiratory tract tissue was noted in these groups. What they are and what they do article pdf available in microscopy today 81. Thermo fisher scientific paraformaldehyde revision date 01apr20 s indicates a substance that is identified in a proposed or final significant new use rule t indicates a substance that is the subject of a section 4 test rule under tsca. Is there a big difference between using formaldehyde or. Paraformaldehyde is a white crystalline powder of polymerized formaldehyde, a flammable solid that can emit formaldehyde gas when heated or mixed with water. Page 17 safety data sheet according to 19072006ec, article 31 printing date 19.
Microwave 18 ml of pbs in a 50ml tube placed in a beaker with water until water starts to boil leave lid of tube slightly ajar. Safety data sheet msds for information on this product, which is described as a severe irritant, sensitizer and harmful. Formaldehyde, the decomposition product of paraformaldehyde, has been listed as a carcinogen by ntp and iarc. Information about 10% formalin the fixative 10% buffered formalin is commonly used to preserve tissues for routine histology in many labs. Download fulltext pdf formaldehyde, formalin, paraformaldehyde and glutaraldehyde. Paraformaldehyde revision date 18jan2018 component casno weight % paraformaldehyde 30525894 90 4. This might be called paraformaldehyde, but it actually isnt because its not the polymer form. When dissolved in solution, it gets depolymerised to formaldehyde which fixes the tissues and cellulose antigens while retaining cellular and.
Methylene oxide, ac4553, ac4554, 41860, 41883 supplier. Use precautions against formaldehyde exposure when opening containers or entering a poorly ventilated storage area. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Wmish pfa crosslinks the biomolecules of the cell, acting as scaffolding that anchors the mrna. Do not handle until all safety precautions have been read and understood. Identification of the substancemixture and of the companyundertaking. Paraformaldehyde 16% solution, em grade article number. It is in our food chain and is a natural product of cell metabolism but it is also a product of automobile and truck combustion, cooking of our food, the fixing of tissue in research and pathology laboratories, the embalming of the dead and the production of a wide array of. Paraformaldehyde polyoxymethylene ch2o n 30,03 gmol concentration casno. Paraformaldehyde, formadehyde and formalin duke light.
Formaldehyde was also present at concentrations of 3. View product specific information, msds, references and buying faq. May react with bases sodium hydroxide, potassium hydroxide, ammonia, and. Paraformaldehyde commonly has a slight odor of formaldehyde due to decomposition. While paraformaldehyde has not been identified as a carcinogen, it should be handled with caution since formaldehyde t he monomer from which it is made is a carcinogen. Pd olson notes fixative for immunocytochemistry of fresh tissues e. Working with paraformaldehyde powder and, to a lesser extent, flakes or granules, can expose employees to paraformaldehyde dust, which is a strong irritantsensitizer. Sds of paraformaldehyde, safety data sheets, cas 30525894. This solution may be stored at room temperature for at least one year without change of the original quality. No component of this product present at levels greater than or equal to 0.
As our channel brand, vwr offers an integrated, seamless purchasing experience that is optimized for the way our. Download msds pdf search msds currently available for download bioworld offers formaldehyde 4% in pbs for your research at low price. Paraformaldehyde has widespread acceptance as an additive to stop fermentation of the starch on oilwelldrilling muds. Formaldehyde, formalin, paraformaldehyde safe work practices. Wash spillages into an effluent treatment plant or proceed as follows.